Research published on October 29, 2025, in the Journal of Periodontology indicates a significant association between antidepressant use and a reduced prevalence of periodontitis. The study, conducted by a team led by María Martínez at University Complutense in Madrid, examined data from 9,839 participants in the U.S. National Health and Nutrition Examination Survey from 2009 to 2014.
The findings reveal that the overall prevalence of periodontitis stood at 35.3% for moderate cases and 11.1% for severe cases. Notably, the researchers found that antidepressant use was associated with significantly lower odds of developing periodontitis across various definitions. This protective effect was particularly pronounced for severe forms of the disease, with an adjusted odds ratio of 0.68 for advanced periodontitis (stages III to IV) and an odds ratio of 0.41 for severe periodontitis.
The link between mental health and oral health has been acknowledged for some time. Ana Becil Giglio, president of the American Academy of Periodontology, remarked, “We have known for a long time that depression and gum disease can influence each other. This study adds an intriguing new layer, suggesting that antidepressant use may help protect against severe forms of periodontal disease.”
These results highlight the importance of addressing mental health not only for its psychological benefits but also for its potential role in oral health. Given the substantial numbers of individuals affected by both depression and periodontitis, further investigation into how antidepressants might offer protective effects is warranted.
This study serves as a crucial reminder of the interconnectedness of mental and physical health. As more research emerges, healthcare providers may consider the implications of these findings in their treatment approaches, particularly for patients struggling with both depression and oral health issues.
For those interested in the detailed findings, the article by María Martínez et al titled “Reduced prevalence of periodontitis in antidepressant users: Findings from a large-scale US sample” can be accessed in the Journal of Periodontology.
